Josep Serrano-Serrat
Sociological Science August 6, 2026
10.15195/v13.a36
Abstract
Although quantitative social sciences often rely on estimating models in which treatment effects vary across groups, researchers rarely specify which causal quantity they aim to estimate or justify their empirical modeling choices. This article makes two contributions. First, it clarifies the distinct quantities of interest when studying interactions: comparisons at different treatment intensities (the difference in conditional average marginal effects) and comparisons at similar intensities (what I term the average interactive partial effect). When treatment effects are nonlinear and treatment distributions differ across groups, these quantities diverge. Second, the article assesses estimation strategies to estimate these quantities. It demonstrates that linear interaction models produce biased estimates of either quantity when treatment effects are nonlinear and explores two alternatives that explicitly accommodate such nonlinearities. This article is accompanied by an R package that implements these approaches. Through simulations, stylized examples, and an empirical application, the article shows that explicitly defining the quantity of interest and selecting appropriate models is essential for valid interaction analysis.
Although quantitative social sciences often rely on estimating models in which treatment effects vary across groups, researchers rarely specify which causal quantity they aim to estimate or justify their empirical modeling choices. This article makes two contributions. First, it clarifies the distinct quantities of interest when studying interactions: comparisons at different treatment intensities (the difference in conditional average marginal effects) and comparisons at similar intensities (what I term the average interactive partial effect). When treatment effects are nonlinear and treatment distributions differ across groups, these quantities diverge. Second, the article assesses estimation strategies to estimate these quantities. It demonstrates that linear interaction models produce biased estimates of either quantity when treatment effects are nonlinear and explores two alternatives that explicitly accommodate such nonlinearities. This article is accompanied by an R package that implements these approaches. Through simulations, stylized examples, and an empirical application, the article shows that explicitly defining the quantity of interest and selecting appropriate models is essential for valid interaction analysis.
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Supplemental Materials
Reproducibility Package: All code necessary to replicate this study is available in an OSF repository at https://osf.io/8tx6g/.
- Citation: Serrano-Serrat, Josep. 2026. “Quantities of Interest for Interactions and the Pitfalls of Assuming Linear Treatment Effects” Sociological Science 13:945-970.
- Received: March 11, 2026
- Accepted: June 23, 2026
- Editors: Arnout van de Rijt, Kristian B. Karlson
- DOI: 10.15195/v13.a36



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