Schools as Moderators of Genetic Associations with Life Course Attainments: Evidence from the WLS and Add Health

Sam Trejo, Daniel W Belsky, Jason D. Boardman, Jeremy Freese, Kathleen Mullan Harris, Pam Herd, Kamil Sicinski, Benjamin W. Domingue

Sociological Science, August 2, 2018
10.15195/v5.a22


Genetic variants identified in genome-wide association studies of educational attainment have been linked with a range of positive life course development outcomes. However, it remains unclear whether school environments may moderate these genetic associations. We analyze data from two biosocial surveys that contain both genetic data and follow students from secondary school through mid- to late life. We test if the magnitudes of the associations with educational and occupational attainments varied across the secondary schools that participants attended or with characteristics of those schools. Although we find little evidence that genetic associations with educational and occupational attainment varied across schools or with school characteristics, genetic associations with any postsecondary education and college completion were moderated by school-level socioeconomic status. Along similar lines, we observe substantial between-school variation in the average level of educational attainment students achieved for a fixed genotype. These findings emphasize the importance of social context in the interpretation of genetic associations. Specifically, our results suggest that though existing measures of individual genetic endowment have a linear relationship with years of schooling that is relatively consistent across school environments, school context is crucial in connecting an individual’s genotype to his or her likelihood of crossing meaningful educational thresholds.
Creative Commons LicenseThis work is licensed under a Creative Commons Attribution 4.0 International License.

Sam Trejo: Graduate School of Education, Stanford University
E-mail: samtrejo@stanford.edu.

Daniel W. Belsky: Duke University School of Medicine and Social Science Research Institute
E-mail: dbelsky@duke.edu

Jason D. Boardman: Institute of Behavioral Science and Sociology Department, University of Colorado Boulder
E-mail: boardman@colorado.edu

Jeremy Freese: Department of Sociology, Stanford University
E-mail: jfreese@stanford.edu

Kathleen Mullan Harris: Department of Sociology and Carolina Population Center, University of North Carolina at Chapel Hill
E-mail: kathie_harris@unc.edu

Pam Herd: Department of Sociology and La Folette School of Public Affairs, University of Wisconsin–Madison
E-mail: pherd@lafollette.wisc.edu

Kamil Sicinski: Center for Demography of Health and Aging, University of Wisconsin–Madison.
E-mail: ksicinsk@ssc.wisc.edu

Benjamin W. Domingue: Graduate School of Education, Stanford University
E-mail: bdomingue@stanford.edu

Acknowledgements: This work has been supported (in part) by award 96-17-04 from the Russell Sage Foundation and the Ford Foundation, the National Science Foundation Graduate Research Fellowship Program under grant DGE-1656518 (Trejo), the Institute of Education Sciences under grant R305B140009 (Trejo), and a Jacobs Foundation Early Career Research Fellowship (Belsky). This research uses Add Health GWAS data funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development grant R01 HD073342 to Kathleen Mullan Harris and the Eunice Kennedy Shriver National Institute of Child Health and Human Development and National Institutes of Health grant R01 HD060726 to Harris, Boardman, and McQueen. Add Health is a program project directed by Kathleen Mullan Harris and designed by J. Richard Udry, Peter S. Bearman, and Kathleen Mullan Harris at the University of North Carolina at Chapel Hill; it is funded by grant P01 HD31921 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development with cooperative funding from 23 other federal agencies and foundations. The Wisconsin Longitudinal Study is directed by Pamela Herd, and the work conducted herein was supported by the National Institute on Aging (R01 AG041868-01A1 and P30 AG017266). This research benefitted from GWAS results made available by the Social Science Genetic Association Consortium. Any opinions expressed are those of the author(s) alone and should not be construed as representing the opinions of each foundation.

  • Citation: Trejo, Sam, Daniel W. Belsky, Jason D. Boardman, Jeremy Freese, Kathleen Mullan Harris, Pam Herd, Kamil Sicinski, and Benjamin W. Domingue. 2018. “Schools as Moderators of Genetic Associations with Life Course Attainments: Evidence from the WLS and Add Health.” Sociological Science 5: 513-540.
  • Received: March 20, 2018
  • Accepted: April 16, 2018
  • Editors: Kim Weeden
  • DOI: 10.15195/v5.a22


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